2024

Wen W and Turrigiano GG (2024) Keeping your brain in balance: homeostatic regulation of network function. Annu Rev Neurosci

Wen W and Turrigiano GG (2024) Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits. BioRxiv

2023

Bottorff J, Padgett S, and Turrigiano GG (2023) Basal forebrain cholinergic activity is necessary for upward firing rate homeostasis in the rodent visual cortex. PNAS 23:e2317987121

2022

Groves Kuhnle C, Grimes M, Suarez Casanova VM, Turrigiano GG, and Van Hooser S (2022) Juvenile Shank3 knockout mice adopt distinct hunting strategies during prey capture learning. ENEURO.0230-22.2022

Wu CH, Tatavarty V, Jean Beltran PM, Guerrero AA, Keshishian H, Drug K, MacMullan MA, Li L, Carr SA, Cottrell JR, and Turrigiano GG (2022). A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling. Elife 11:e&4277 doi: 10.7554/elife.74277

Tereshko L, Turrigiano GG, and Sengupta P (2022) Primary cilia in the postnatal brain: subcellular compartments for organizing neuromodulatory signaling. Curr Opin Neurobiol. 74:102533

Ramos R, Wu CH, and Turrigiano GG (2022) Strong Aversive Conditioning Triggers a long-lasting generalized aversion. Front Cell Neurosci 16:854315

2021

Wen W, Turrigiano GG (2021) Developmental regulation of homeostatic plasticity in mouse primary visual cortex. J Neurosci. 41:9891-9895

Cary BA, Turrigiano GG. Stability of neocortical synapses across sleep and wake states during the critical period in rats. eLife. doi: 10.7554/eLife.66304

Trojanowski NF, Turrigiano GG. CaMKIV signaling is not essential for the maintenance of intrinsic or synaptic properties in mouse visual cortex. eNeuro. 2021 May 12:ENEURO.0135-21.2021

Wu CH, Ramos R, Katz DB, and Turrigiano GG (2021) Homeostatic synaptic Scaling Establishes the Specificity of an Associative Memory. Current Biology 2021 Jun 7;31(11):2274-2285.e5

Tereshko L, Gao Y, Cary B, Turrigiano GG, and Sengupta P (2021) Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons. eLife 2021;10:e65427

Torrado Pacheco A, Bottorff J, and Turrigiano GG (2021) Sleep promotes downward firing rate homeostasis. Neuron, 109(3):530-544.e6.

Trojanowski NF, Bottorff J, and Turrigiano GG (2021) Activity labeling in vivo using CaMPARI2 reveals electrophysiological differences between neuron with high and low firing rate set points. Neuron, 109(4):663-676.e5.

2020

Tatavarty V, Torrado Pacheco A, Groves Kuhnle C, Lin H, Koundinya P, Miska NK, Hengen KB, Wagner FF, Van Hooser SD, and Turrigiano GG (2020) Autism-associated Shank3 is essential for homeostatic compensation in rodent V1. Neuron, 106:769-777

Wu YK Hengen KB, Turrigiano GG, and Gjorgjieva J (2020) Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics. PNAS

2019

Torrado Pacheco A, Tilden EI, Grutzner SM, Lane BJ, Wu Y, Hengen KB, Gjorgjieva J, and Turrigiano, GG (2019) Rapid and Active Stabilization of Visual Cortical Firing Rates Across Light-Dark Transitions. PNAS

Ma Z, Turrigiano GG, Wessel R, Hengen KB (2019) Critical Dynamics are a homeostatic set point of cortical networks in vivo. Neuron, 104(4):655-664.e4

2018

Miska N, Richter L, Cary B, Gjorgjieva J, and Turrigiano GG (2018) Sensory Deprivation Independently Regulates Neocortical Feedforward and Feedback Excitation-Inhibition Ratio. eLife,

Moeyeart G, Holt G, Madangopal R, Perez-Alverez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eichkolt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, and Schreiter ER (2018) Improved methods for marking active neuron populations. Nature Comm 9:4440

2017

Joseph, A, Turrigiano GG (2017) All for One but Not One for All: Excitatory Synaptic Scaling and Intrinsic plasticity are co-regulated by CaMKIV. J Neurosci. 37:6778-6785

Nahmani M, Lanahan C, DeRosier D, Turrigiano GG. (2017) High-numerical-aperture cryogenic light microscopy for inceased precision of superresolution reconstructions. PNAS pii: 201618206. doi: 10.1073/pnas.1618206114

Turrigiano, GG (2017) The dialectic of Hebb and homeostasis. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715). pii: 20160258. doi: 10.1098/rstb.2016.0258. Review.

2016

Hengen KB, Torredo Pacheco A, McGregor J, Van Hooser S, and Turrigiano GG (2016) Neuronal firing rate homeostasis is inhibited by sleep and promoted by active wake. Cell, 165:180-91. doi: 10.1016/j.cell.2016.01.046

Steinmetz CC, Tatavarty V, Sugino K, Shima Y, Joseph A, Lin H, Rutlin M, Lambo M, Hempel CM, Okaty BW, Paradis S, Nelson SB, Turrigiano GG. (2016) Upregulation of u3A drives homeostatic plasticity by rerouting AMPAR into the recycling endosomal pathway. Cell Rep. 2016 Sep 6;16(10):2711-22. doi: 10.1016/j.celrep.2016.08.009.

2015

Gainey M, Tatavarty V, Nahmani M., Lin H., and Turrigiano GG (2015) Activity-dependent Synaptic GRIP1 Accumulation Drives Synaptic Scaling Up in Response to Action Potential Blockade. PNAS 112:E3590-9

2014

Nahmani M, Turrigiano GG (2014) Deprivation-induced strengthening of presynaptic and postsynaptic inhibitory transmission in Layer 4 of visual cortex during the critical period.

J Neurosci. 34:2671-82

Nahmani M, Turrigiano GG (2014) Adult cortical plasticity following injury: recapitulation of critical period mechanisms? Neuroscience pii: S0306-4522(14)00331-5. doi: 10.1016/j.neuroscience.2014.04.029

Turrigiano, G.G. (2014) Keeping a Lid on it. Nature. 2014 Jul 17;511(7509):297-8.

Taft CE and Turrigiano GG (2014) PSD-95 promotes the stabilization of young synaptic contacts. Philo. Trans Royal Soc. Lond. B. Biol. Sci. 369: 20130134

2013

Lambo ME and Turrigiano, GG (2013) Synaptic and Intrinsic Homeostatic Mechanisms Cooperate to Increase L2/3 Pyramidal Neuron Excitability During a Late Phase of Critical Period Plasticity. J Neurosci, 33:8810-8819

Tatavarty V, Sun Q, and Turrigiano, G.G. (2013) How to Scale Down Postsynaptic Strength. J Neurosci. 33:13179-89.

Hengen KB, Lambo ME, Van Hooser S, Katz DB, and Turrigiano, G.G. (2013) Firing Rate Homeostasis in Visual Cortex of Freely Behaving Rodents. Neuron 80:335-42

Loebrich S, Djukic B, Tong ZJ, Cottrell JR, Turrigiano GG, and Nedivi E (2013) Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. PNAS 110(47):E4548-56.

Lefort S, Gray AC, Turrigiano GG (2013) Long-term inhibitory plasticity in visual cortical layer 4 switches sign at the opening of the critical period. PNAS, 110(47):E4540-7.

2012

Turrigiano, G (2012) Homeostatic Synaptic Plasticity: Global and Local Mechanisms for Stabilizing Neuronal Function. Cold Spring Harb Perspect Biol. 1;4(1):a005736

Blackman MP, Nelson SB, and Turrigiano GG (2012) A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up. J Neurosci, 32(39):13529-36

Alivisatos AP, Andrews AM, Boyden ES, Chun M, Church GM, Deisseroth K, Donoghue JP, Fraser SE, Lippincott-Schwartz J, Looger LL, Masmanidis S, McEuen PL, Nurmikko AV, Park H, Peterka DS, Reid C, Roukes ML, Scherer A, Schnitzer M, Sejnowski TJ, Shepard KL, Tsao D, Turrigiano G, Weiss PS, Xu C, Yuste R, Zhuang X. Nanotools for neuroscience and brain activity mapping (2012). ACS Nano 7:1850-1866

2011

Sun, Q, and Turrigiano, GG (2011) PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down. J. Neurosci. 31:6800-6808

Turrigiano, G (2011) Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement. Ann. Rev. Neurosci. 34:89-103

Nataraj K. and Turrigiano, G (2011) Regional and Temporal Specificity of Intrinsic Plasticity Mechanisms in Rodent Primary Visual Cortex. J Neurosci, 31:17932-40

2010

Maffei, A., Lambo, M., and Turrigiano, G.G (2010) Critical period for inhibitory plasticity in binocular visual cortex. J Neurosci, 30:33304-3309

Nataraj, K., Le Roux, N., LeFort, S., Nahmani, M., and Turrigiano, G.G, (2010) Visual deprivation selectively suppresses L5 pyramidal neuron excitability by preventing the induction of intrinsic plasticity. Neuron, 68:750-762

Steinmetz, C., and Turrigiano, GG (2010) TNFα Signaling maintains the ability of cortical synapses to express synaptic scaling. J. Neurosci, 30:15685-14690

Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, Block ML, Zecca L, Hong JS, Dantzer R, Kelley KW, Craig AD (2010). Ten years of nature reviews neuroscience: insights from the highly cited. Nat. Rev. Neurosci. 11:718-726

2009

Bracken, B. and Turrigiano, G (2009) Experience-dependent regulation of TrkB isoforms in rodent visual cortex. Dev. Neurobiol. 69:267-278

Gainey M., Hurvitz-Wolff J., Lambo, M., and Turrigiano G.G. (2009) Synaptic scaling in neocortical neurons requires the GluR2 subunit of the AMPA receptor. J Neurosci., 29:6479-6489

Ehlers, M and Turrigiano, G. (2009) Signaling Mechanisms. Curr. Opin. Neurobiol. 19:253-256

2008

Pratt, K., Taft, CE, Burbea, M., and Turrigiano, GG (2008) Dynamics underlying synaptic gain between pairs of cortical pyramidal neurons. Dev. Neurobiol. 68(2):143-51

Ibata, K., Sun, Q., and Turrigiano, G.G. (2008) Rapid synaptic scaling induced by changes in postsynaptic firing. Neuron, 57:819-826.

Maffei, A., and Turrigiano, G.G. (2008) Multiple modes of network homeostasis in visual cortical layer 2/3. J. Neurosci., 28:4377-4384.

Maffei, A. and Turrigiano, G (2008) The Age of Plasticity: Developmental Regulation of Synaptic Plasticity in Neocortical Microcircuits. Prog Brain Res 169:211-23

Turrigiano, G (2008) The self-tuning neuron: synaptic scaling of excitatory synapses. Cell, 135:422-435

Nelson, SB and Turrigiano, GG (2008) Strength through diversity. Neuron 60:477-482

2007

Sjöström, P.J., Turrigiano, G.G. and Nelson, S.B. (2007) Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses. J. Neuropharm. 52(1):176-84

Giorgi, C., Yeo, GW., Stone, ME, Katz, DB, Burge, C., Turrigiano, G.G., and Moore, MJ (2007) The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Cell 130:179-191

Turrigiano, Gina G (2007) Homeostatic signaling: the positive side of negative feedback. Curr. Opin. Neurobiol. 17:318-324

2006

Maffei, A., Nataraj, K., Nelson, S.B., and Turrigiano, G.G. (2006) Potentiation of cortical inhibition by visual deprivation. Nature, 443:81-84

Turrigiano, G.G. (2006) Maintaining your youthful spontaneity: microcircuit homeostasis in the embryonic spinal cord. Neuron 49:481-485

Turrigiano, G.G. (2006) More than a sidekick: glia and homeostatic synaptic plasticity. Trends Mol. Medicine 12:458-60

Wierenga, C., Walsh, M., and Turrigiano, G.G. (2006) Temporal regulation of the expression locus of homeostatic plasticity. J. Neurophysiol., 96:2127-2133

2005

Wierenga, C, Ibata, K, and Turrigiano, G.G. (2005) Postsynaptic expression of Homeostatic synaptic plasticity at neocortical synapses. J. Neurosci. 25:2895-2905

Dani, V., Chanage, Q., Maffei, A., Turrigiano, G., Jaenisch, R., and Nelson, S (2005) Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. PNAS 102: 12560-12565

2004

Watt, A., Sjostrom, P.J., Hausser, M., Nelson, S.B., and Turrigiano, G.G. (2004) A Proportional but slower NMDA potentiation follows AMPA potentiation in LTP. Nature Neurosci., 7:518-524

Cudmore, R.H. and Turrigiano, G.G. (2004) Long-term increase in intrinsic excitability following a short period of action potential firing in LV visual cortical neurons. J Neurophysiol., 92:341-348

Turrigiano, G.G., Nelson, S.B. (2004) Homeostatic Plasticity in Developing Cortical Networks.

Nature Reviews Neurosci. 5:97-10

Maffei, A, Nelson, S.B., and Turrigiano, G.G. (2004) Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation. Nature Neurosci. 12:1353-1359

Turrigiano, G.G. (2004) A competitive game of synaptic tag. Neuron 44:917-923

Sjöström, P.J., Turrigiano, G.G. and Nelson, S.B. (2004) Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spiking. J. Neurophysiol. 92:3338-3343

2003

Myme, C.O., Sugino, K., Turrigiano, G.G., and Nelson, S.B. (2003) The NMDA to AMPA ratio at synapses onto layer 2/3 pyramidal neurons is conserved across prefrontal and visual cortices. J. Neurophysiol., 90:771-779

Pratt KG, Watt AJ, Griffith LC, Nelson SB, and Turrigiano GG (2003) Activity-Dependent Remodeling of Presynaptic Inputs by Postsynaptic Expression of Activated CaMKII. Neuron 39:269-281

Sjöström, P.J., Turrigiano, G.G. and Nelson, S.B. (2003) Neocortical LTD via Coincident activation of presynaptic NMDA and cannabinoid receptors. Neuron 39:641-654

2002

Desai NS, Cudmore, R.H, Nelson SB, and Turrigiano GG (2002) Critical Periods for Experience-dependent synaptic scaling in visual cortex. Nature Neurosci. 5: 783-789

Kilman, V, van Rossum, M.C., and Turrigiano, G.G. (2002) Activity Scales Inhibitory Synaptic strengths by Regulating the Number of Postsynaptic GABAa Receptors. J. Neurosci, 22:1328-1337

Turrigiano, G.G. (2002) A recipe for ridding synapses of the ubiquitous AMPA receptor. TINS

Van Rossum, M.C., Turrigiano, G.G., and Nelson, S.B. (2002) Fast propagation of firing rates through layered networks of noisy neurons. J. Neurosci., 22:1956-1966

2001

Leslie, K.R, Nelson, S.B., and Turrigiano, G.G. (2001) Postsynaptic Depolarization Scales Quantal Amplitude in Neocortical Pyramidal Neurons. J. Neurosci. 21: RC170

Sjöström, P.J., Turrigiano, G.G. and Nelson, S.B. (2001) Rate, timing, and cooperativity jointly determine cortical synaptic plasticity. Neuron, 32:1149-1164

2000

Hemple, C., Hartman, K., Turrigiano, G.G., and Nelson, S.B. (2000) Multiple Forms of Short-term Synaptic Plasticity in Prefronal Cortex. J. Neurophysiol., 83:3031-3041.

Turrigiano, G.G. (2000) AMPA receptors unbound: membrane cycling and synaptic plasticity. Neuron 26:5-8

Turrigiano, G.G. and Nelson, S.B. (2000) Hebb and Homeostasis in Neuronal Plasticity. Current Opinion in Neurobiology, 10:358-364.

Watt, A., van Rossum, M., MacLeod, K., Nelson, S.B., and Turrigiano, G.G. (2000) Activity Co-regulates Quantal AMPA and NMDA Currents at Neocortical Synapses. Neuron, 26:659-670

Van Rossum, M.C., Bi, G.Q., and Turrigiano, G.G. (2000) Stable Hebbian Learning from Spike-Timing Dependent Plasticity. J. Neurosci. 20:8812-8821

1999

Desai, N.S., Rutherford, L.C., and Turrigiano, G.G. (1999). Plasticity in the intrinsic excitability of neocortical pyramidal neurons. Nature Neuroscience 2:515-520

Desai, N.S., Wang, X.-J., and Turrigiano, G.G. (1999) Activity-dependent changes in the balance of inward and outward currents can account for changes in pyramidal neuron excitability. Nature Neuroscience Web supplement

Varela, J.A., Song, S., Turrigiano, G.G., and Nelson, S.B. (1999) Differential depression at excitatory and inhibitory synapses in visual cortex. J. Neurosci. 19:4293-4304

Desai, N.S. Rutherford L.C., Nelson, S.B. and Turrigiano, G.G. (1999) Activity-dependent regulation

of excitability in rat visual cortical neurons. Neurocomputing, 27:101-106

Desai, N.S., Rutherford, L.C., and Turrigiano, G.G. (1999) BDNF regulates the intrinsic excitability of cortical neurons. Learning and Memory 6:284-291

1998

Turrigiano, G.G., Leslie, K.R, Desai, N.S, Rutherford, L.C., and Nelson, S.B. (1998) Activity-dependent scaling of quantal amplitude in neocortical neurons. Nature 391:892-895

Turrigiano, G.G. and Nelson, S.B. (1998) Thinking globally, acting locally: AMPA receptor turnover and synaptic strength. Neuron, 21:933-941

Rutherford L.C., Nelson S.B., and Turrigiano, G.G. (1998) Opposite effects of BDNF on the quantal amplitude of pyramidal and interneuron excitatory synapses. Neuron 21:521-530

1997

Lockhart, S., Turrigiano, G.G., and Birren S.J. (1997) Nerve Growth Factor modulates synaptic connections between sympathetic neurons and cardiac myocytes. J. Neurosci. 17:9573-9582

Rutherford, L.C., DeWan, A., Lauer, H., and Turrigiano, G.G. (1997) BDNF mediates the activity-dependent regulation of inhibition in neocortical cultures. J. Neurosci. 17:4527-4535

Earlier publications

Turrigiano, G.G and A.I. Selverston (1990) A cholecystokinin-like hormone activates a feeding-related neural circuit in lobster. Nature 344:866-868

Turrigiano, G.G., L.F. Abbott, and E. Marder (1994) Activity-dependent changes in the intrinsic properties of cultured neurons. Science 264:974-976

Turrigiano, G.G., G. Le Masson, and E. Marder (1995) Selective regulation of current densities underlies spontaneous changes in the activity of cultured neurons. J. Neurosci. 15:3640-6552

Turrigiano, G.G., E. Marder, and L.F. Abbott (1996) Cellular short term memory from a slow potassium conductance. J. Neurophys. 75:963-966